Deconstructing a Disease: RAR, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia
IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …
PML protein isoforms and the RBCC/TRIM motif
K Jensen, C Shiels, PS Freemont - Oncogene, 2001 - nature.com
PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein
was originally discovered in patients suffering from acute promyelocytic leukaemia (APL) …
was originally discovered in patients suffering from acute promyelocytic leukaemia (APL) …
The transcriptional role of PML and the nuclear body
S Zhong, P Salomoni, PP Pandolfi - Nature cell biology, 2000 - nature.com
The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear
domain, the nuclear body. Various functions have been attributed to the PML nuclear body …
domain, the nuclear body. Various functions have been attributed to the PML nuclear body …
Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA
FM Boisvert, MJ Hendzel, DP Bazett-Jones - The Journal of cell biology, 2000 - rupress.org
The promyelocytic leukemia (PML) nuclear body (also referred to as ND10, POD, and Kr
body) is involved in oncogenesis and viral infection. This subnuclear domain has been …
body) is involved in oncogenesis and viral infection. This subnuclear domain has been …
Retinoids in chemoprevention and differentiation therapy
LA Hansen, CC Sigman, F Andreola, SA Ross… - …, 2000 - academic.oup.com
Retinoids are essential for the maintenance of epithelial differentiation. As such, they play a
fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation …
fundamental role in chemoprevention of epithelial carcinogenesis and in differentiation …
Gene expression networks underlying retinoic acid–induced differentiation of acute promyelocytic leukemia cells
TX Liu, JW Zhang, J Tao, RB Zhang… - Blood, The Journal …, 2000 - ashpublications.org
To elucidate the molecular mechanism of all-trans-retinoic acid (ATRA)–induced
differentiation of acute promyelocytic leukemia (APL) cells, the gene expression patterns in …
differentiation of acute promyelocytic leukemia (APL) cells, the gene expression patterns in …
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
S Rokudai, O Laptenko, SM Arnal… - Proceedings of the …, 2013 - National Acad Sciences
Monocytic leukemia zinc finger (MOZ)/KAT6A is a MOZ, Ybf2/Sas3, Sas2, Tip60 (MYST)-type
histone acetyltransferase that functions as a coactivator for acute myeloid leukemia 1 protein …
histone acetyltransferase that functions as a coactivator for acute myeloid leukemia 1 protein …
Transcriptional regulation in acute promyelocytic leukemia
It has been 10 years since the seminal discovery that a mutant form of a retinoid acid
receptor (RARα) is associated with acute promyelocytic leukemia (APL). This finding …
receptor (RARα) is associated with acute promyelocytic leukemia (APL). This finding …
SUMO-1 protease-1 regulates gene transcription through PML
JL Best, S Ganiatsas, S Agarwal, A Changou… - Molecular cell, 2002 - cell.com
During a screen to identify c-Jun activators, we isolated a cysteine protease, SuPr-1, that
induced c-Jun-dependent transcription independently of c-Jun phosphorylation. SuPr-1 is a …
induced c-Jun-dependent transcription independently of c-Jun phosphorylation. SuPr-1 is a …
Tumor suppressors having oncogenic functions: the double agents
Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …