Mechanisms and functions of long non-coding RNAs at multiple regulatory levels
X Zhang, W Wang, W Zhu, J Dong, Y Cheng… - International journal of …, 2019 - mdpi.com
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …
interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression …
The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation
HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy
L Morera, M Lübbert, M Jung - Clinical epigenetics, 2016 - Springer
The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …
alterations of the DNA sequence. In the last years, it has become more and more evident …
[HTML][HTML] Influence of metabolism on epigenetics and disease
WG Kaelin, SL McKnight - Cell, 2013 - cell.com
Chemical modifications of histones and DNA, such as histone methylation, histone
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …
acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy
Diabetic retinopathy remains the major cause of blindness among working age adults.
Although a number of metabolic abnormalities have been associated with its development …
Although a number of metabolic abnormalities have been associated with its development …
Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism
S Nitsch, L Zorro Shahidian, R Schneider - EMBO reports, 2021 - embopress.org
In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …
Chromatin architecture can be modified by various post‐translational modifications of …
Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress
ME Neganova, SG Klochkov, YR Aleksandrova… - Seminars in Cancer …, 2022 - Elsevier
Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …
Epigenetic gene silencing in cancer–a mechanism for early oncogenic pathway addiction?
Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …
progression. The best characterized are epigenetically mediated transcriptional-silencing …