Biopharmaceuticals are making increasing impact on medicine, including treatment of
indications in the eye. Macromolecular drugs are typically given by physician-administered …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

PURPOSE: Recent clinical studies show that a single intravitreal injection of the
corticosteroid triamcinolone acetonide (TAA) may reduce edematous retinal swelling and …

Corneal neovascularization (CNV) may be a physiological response to various stimuli, but a
chronic and persistent upregulation of neoangiogenesis can result in pathological CNV …

A model of the axial change in ocular parameters of the guinea pig eye from 2 to 825 days of
age was developed and a corresponding paraxial schematic eye model applicable from 2 to …

PURPOSE: To provide a conceptual framework for the development and use of combination
therapies for choroidal neovascularization secondary to age-related macular degeneration …

Abstract Rationale: Corneal neovascularization (CoNV) is a severe complication of various
types of corneal diseases, that leads to permanent visual impairment. Current treatments for …

Corneal angiogenesis is associated with a variety of corneal diseases, and is sometimes
vision threatening. In recent years, with the discovery of major pro-and anti-angiogenic …

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins
(PGs), which play a significant role in health and disease in the gastrointestinal tract (GI) and …

Under healthy conditions, the cornea is an avascular structure which allows for transparency
and optimal visual acuity. Its avascular nature is maintained by a balance of proangiogenic …