Controlling Much? Viral Control of Host Chromatin Dynamics

LE Kelnhofer-Millevolte, EA Arnold… - Annual Review of …, 2024 - annualreviews.org
Viruses are exemplary molecular biologists and have been integral to scientific discovery for
generations. It is therefore no surprise that nuclear replicating viruses have evolved to …

The MCM2-7 Complex: Roles beyond DNA Unwinding

BD Rankin, S Rankin - Biology, 2024 - mdpi.com
Simple Summary Here, we summarize what is known about the non-replication roles of
MCM helicase, best known for its ability to unwind double-stranded DNA templates during …

[HTML][HTML] Multiscale molecular modeling of chromatin with MultiMM: From nucleosomes to the whole genome

S Korsak, K Banecki, D Plewczynski - Computational and Structural …, 2024 - Elsevier
Motivation: We present a user-friendly 3D chromatin simulation model for the human
genome based on OpenMM, addressing the challenges posed by existing models with use …

LoopSage: An energy-based Monte Carlo approach for the loop extrusion modeling of chromatin

S Korsak, D Plewczynski - Methods, 2024 - Elsevier
The connection between the patterns observed in 3C-type experiments and the modeling of
polymers remains unresolved. This paper presents a simulation pipeline that generates …

[图书][B] Vertebrate Pattern Formation

M Mallo - 2024 - books.google.com
Vertebrate Pattern Formation, Volume 159 in the Current Topics in Developmental Biology
series, highlights advances in the field, with this volume presenting interesting chapters on …

The‬‭ challenge‬‭ of‬‭ chromatin‬‭ model‬‭ comparison‬‭ and‬‭ validation‬‭ a‬‭ project‬‭ from‬‭ the‬ first international 4D Nucleome Hackathon‬

J Kubica, S Korsak, AB Clerkin, D Kouril, D Schirman… - bioRxiv, 2024 - biorxiv.org
The computational modeling of chromatin structure is highly complex and challenging due to
the hierarchical organization of chromatin, which reflects its diverse biophysical principles …

Shaping gene expression and its evolution by chromatin architecture and enhancer activity.

J Mañes-García, R Marco-Ferreres… - Current Topics in …, 2024 - europepmc.org
Transcriptional regulation plays a pivotal role in orchestrating the intricate genetic programs
governing embryonic development. The expression of developmental genes relies on the …