Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle
stem cells (MuSCs). In this review, we introduce recently developed technologies and the …

Stress is a central concept in biology and has now been widely used in psychological,
physiological, social, and even environmental fields. However, the concept of stress was …

Tissue regeneration declines with ageing but little is known about whether this arises from
changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two …

Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the
capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for …

Normal tissue responses to ionizing radiation have been a major subject for study since the
discovery of X‐rays at the end of the 19th century. Shortly thereafter, time–dose relationships …

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as
it represents a major obstacle to effective cancer treatment. Since tumor cells are highly …

Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive
understanding of distinct subpopulations and their functional relevance in human satellite …