Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Bile acids (BAs) mediate the crosstalk between human and microbial cells and influence
diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) …
diseases including Clostridioides difficile infection (CDI). While bile salt hydrolases (BSHs) …
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Abstract microbeMASST, a taxonomically informed mass spectrometry (MS) search tool,
tackles limited microbial metabolite annotation in untargeted metabolomics experiments …
tackles limited microbial metabolite annotation in untargeted metabolomics experiments …
Microbial metabolites as modulators of host physiology
The gut microbiota is increasingly recognised as a key player in influencing human health
and changes in the gut microbiota have been strongly linked with many non-communicable …
and changes in the gut microbiota have been strongly linked with many non-communicable …
Microbially catalyzed conjugation of GABA and tyramine to bile acids
Bile acids (BAs) are cholesterol-derived molecules that aid in digestion and nutrient
absorption, regulate host metabolic processes, and influence physiology of the gut …
absorption, regulate host metabolic processes, and influence physiology of the gut …
Loss of Bacteroides thetaiotaomicron bile acid-altering enzymes impacts bacterial fitness and the global metabolic transcriptome
Bacteroides thetaiotaomicron (B. theta) is a Gram-negative gut bacterium that encodes
enzymes that alter the bile acid pool in the gut. Primary bile acids are synthesized by the …
enzymes that alter the bile acid pool in the gut. Primary bile acids are synthesized by the …
Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent Clostridioides difficile infection
AS McMillan, G Zhang, MK Dougherty, SK McGill… - Msphere, 2024 - journals.asm.org
Recurrent C. difficile infection (rCDI) is an urgent public health threat, for which the last resort
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
and lifesaving treatment is a fecal microbiota transplant (FMT). However, the exact …
Electrostatic interactions dictate bile salt hydrolase substrate preference
KP Malarney, PV Chang - Biochemistry, 2023 - ACS Publications
The human intestines are colonized by trillions of microbes, comprising the gut microbiota,
which produce diverse small molecule metabolites and modify host metabolites, such as bile …
which produce diverse small molecule metabolites and modify host metabolites, such as bile …
The microbial-derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota
Clostridioides difficile is a Gram-positive, spore-forming anaerobe that causes clinical
diseases ranging from diarrhea and pseudomembranous colitis to toxic megacolon and …
diseases ranging from diarrhea and pseudomembranous colitis to toxic megacolon and …