Metabolite G-protein coupled receptors in cardio-metabolic diseases
D Strassheim, T Sullivan, DC Irwin, E Gerasimovskaya… - Cells, 2021 - mdpi.com
G protein-coupled receptors (GPCRs) have originally been described as a family of
receptors activated by hormones, neurotransmitters, and other mediators. However, in …
receptors activated by hormones, neurotransmitters, and other mediators. However, in …
A preclinical mice model of multiple sclerosis based on the toxin-induced double-site demyelination of callosal and cerebellar fibers
S Vejar, IS Pizarro, R Pulgar-Sepúlveda… - Biological Research, 2024 - Springer
Background Multiple sclerosis (MS) is an irreversible progressive CNS pathology
characterized by the loss of myelin (ie demyelination). The lack of myelin is followed by a …
characterized by the loss of myelin (ie demyelination). The lack of myelin is followed by a …
Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and …
F Casado-Barragán, G Lazcano-Páez, PE Larenas… - Antioxidants, 2023 - mdpi.com
Chronic diabetes mellitus (DM) can lead to kidney damage associated with increased
reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression …
reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression …
Smooth muscle AKG/OXGR1 signaling regulates epididymal fluid acid–base balance and sperm maturation
C Xu, Y Yuan, C Zhang, Y Zhou, J Yang, H Yi… - Life …, 2022 - academic.oup.com
Infertility is a global concern attributed to genetic defects, lifestyle, nutrition, and any other
factors that affect the local metabolism and niche microenvironment of the reproductive …
factors that affect the local metabolism and niche microenvironment of the reproductive …
Activation of 2‐oxoglutarate receptor 1 (OXGR1) by α‐ketoglutarate (αKG) does not detectably stimulate Pendrin‐mediated anion exchange in Xenopus oocytes
JF Heneghan, AJ Majmundar, A Rivera… - Physiological …, 2022 - Wiley Online Library
SLC26A4/Pendrin is the major electroneutral Cl−/HCO3− exchanger of the apical
membrane of the Type B intercalated cell (IC) of the connecting segment (CNT) and cortical …
membrane of the Type B intercalated cell (IC) of the connecting segment (CNT) and cortical …