Extracellular vesicles as tools and targets in therapy for diseases

MA Kumar, SK Baba, HQ Sadida… - Signal transduction and …, 2024 - nature.com
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Exosomes: cell-derived nanoplatforms for the delivery of cancer therapeutics

H Kim, EH Kim, G Kwak, SG Chi, SH Kim… - International journal of …, 2020 - mdpi.com
Exosomes are cell-secreted nanovesicles that naturally contain biomolecular cargoes such
as lipids, proteins, and nucleic acids. Exosomes mediate intercellular communication …

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

X Zhu, M Badawi, S Pomeroy, DS Sutaria… - Journal of …, 2017 - Taylor & Francis
Extracellular vesicles (EVs) are under evaluation as therapeutics or as vehicles for drug
delivery. Preclinical studies of EVs often use mice or other animal models to assess efficacy …

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

P Fuentes, M Sesé, PJ Guijarro, M Emperador… - Nature …, 2020 - nature.com
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90%
of cancer-related deaths. The integrin ITGB3 has been previously described to play an …

Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping

S Rontogianni, E Synadaki, B Li, MC Liefaard… - Communications …, 2019 - nature.com
Extracellular vesicles (EVs) are a potential source of disease-associated biomarkers for
diagnosis. In breast cancer, comprehensive analyses of EVs could yield robust and reliable …

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art

SM Mousavi, SMA Mahdian, MS Ebrahimi… - … Therapy-Nucleic Acids, 2022 - cell.com
Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that
contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived from the …

Non-coding RNAs in breast cancer: intracellular and intercellular communication

CM Klinge - Non-coding RNA, 2018 - mdpi.com
Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

Exosomes as natural delivery carriers for programmable therapeutic nucleic acid nanoparticles (NANPs)

W Ke, KA Afonin - Advanced drug delivery reviews, 2021 - Elsevier
With recent advances in nanotechnology and therapeutic nucleic acids (TNAs), various
nucleic acid nanoparticles (NANPs) have demonstrated great promise in diagnostics and …

Rapid capture of cancer extracellular vesicles by lipid patch microarrays

HY Liu, R Kumar, C Zhong, S Gorji… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) contain various bioactive molecules such as DNA, RNA, and
proteins, and play a key role in the regulation of cancer progression. Furthermore, cancer …

Exosome-based carrier for RNA delivery: progress and challenges

Y Lu, W Huang, M Li, A Zheng - Pharmaceutics, 2023 - mdpi.com
In the last few decades, RNA-based drugs have emerged as a promising candidate to
specifically target and modulate disease-relevant genes to cure genetic defects. The key to …