Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
Using T cell receptor repertoires to understand the principles of adaptive immune recognition
Adaptive immune recognition is mediated by antigen receptors on B and T cells generated
by somatic recombination during lineage development. The high level of diversity resulting …
by somatic recombination during lineage development. The high level of diversity resulting …
OLGA: fast computation of generation probabilities of B-and T-cell receptor amino acid sequences and motifs
Motivation High-throughput sequencing of large immune repertoires has enabled the
development of methods to predict the probability of generation by V (D) J recombination of …
development of methods to predict the probability of generation by V (D) J recombination of …
High-throughput immune repertoire analysis with IGoR
High-throughput immune repertoire sequencing is promising to lead to new statistical
diagnostic tools for medicine and biology. Successful implementations of these methods …
diagnostic tools for medicine and biology. Successful implementations of these methods …
Prediction of specific TCR-peptide binding from large dictionaries of TCR-peptide pairs
I Springer, H Besser, N Tickotsky-Moskovitz… - Frontiers in …, 2020 - frontiersin.org
Current sequencing methods allow for detailed samples of T cell receptors (TCR)
repertoires. To determine from a repertoire whether its host had been exposed to a target …
repertoires. To determine from a repertoire whether its host had been exposed to a target …
Detecting T cell receptors involved in immune responses from single repertoire snapshots
Hypervariable T cell receptors (TCRs) play a key role in adaptive immunity, recognizing a
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …
vast diversity of pathogen-derived antigens. Our ability to extract clinically relevant …
Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity
WS DeWitt III, A Smith, G Schoch, JA Hansen… - Elife, 2018 - elifesciences.org
The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR)
sequences are found in a large number of individual mice and humans. These widely …
sequences are found in a large number of individual mice and humans. These widely …
Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins
MV Pogorelyy, AA Minervina… - Proceedings of the …, 2018 - National Acad Sciences
T cell receptor (TCR) repertoire data contain information about infections that could be used
in disease diagnostics and vaccine development, but extracting that information remains a …
in disease diagnostics and vaccine development, but extracting that information remains a …
TCR-sequencing in cancer and autoimmunity: barcodes and beyond
The T cell receptor (TCR) endows T cells with antigen specificity and is central to nearly all
aspects of T cell function. Each naïve T cell has a unique TCR sequence that is stably …
aspects of T cell function. Each naïve T cell has a unique TCR sequence that is stably …