Disabled-2 (DAB2), a key adaptor protein in clathrin mediated endocytosis, is implicated in
the regulation of key signalling pathways involved in homeostasis, cell positioning and …

Aberrant TGFβ signaling is common in human cancers and contributes to tumor metastasis.
Here, we demonstrate that Gr-1+ CD11b+ myeloid cells are recruited into mammary …

Although Nα-terminal acetylation (Nt-acetylation) is a per-vasive protein modification in
eukaryotes, its general func-tions in a majority of proteins are poorly understood. In 2010, it …

Breast cancer is fast emerging as the leading cancer amongst females, especially in
younger age group in India; a large proportion of these tumors are often aggressive and ER …

Acute and chronic tissue injury results in the generation of a myriad of environmental cues
that macrophages respond to by changing their phenotype and function. This phenotypic …

Activation of canonical Wnt/β-catenin pathway in Invasive Ductal Carcinoma of Breast (IDCs)
was recently reported from our laboratory. Herein, we analyzed promoter methylation status …

The cytokine TGF-β acts as a tumor suppressor in normal epithelial cells and during the
early stages of tumorigenesis. During malignant progression, cancer cells can switch their …

Abstract The disabled homolog 2 (DAB2) gene was recently identified as a tumor
suppressor gene with its expression downregulated in multiple cancer types. The role of …

Abstract Background Human Disabled-2 (DAB2), is a multi-function signalling molecule that
it is frequently down-regulated in human cancers. We aimed to investigate the possible …

Disabled‐2 (Dab2) is a multimodular scaffold protein with signaling roles in the domains of
cell growth, trafficking, differentiation, and homeostasis. Emerging evidences place Dab2 as …