Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …

The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …

Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …

Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …

Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the
causes of this process are still unclear, post-translational modifications of α-synuclein are …

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated
neurodegenerative disorders characterized by the misfolding and aggregation of alpha …

Alpha-synuclein (aSyn) was identified as the main component of inclusions that define
synucleinopathies more than 20 years ago. Since then, aSyn has been extensively studied …

Protein post-translational modifications (PTMs) that potentiate protein aggregation have
been implicated in several neurological disorders, including Alzheimer's (AD) and …

Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are
neurodegenerative disorders resulting in progressive motor/cognitive deficits among other …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …