Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties

A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies

L Chen, D Guttieres, A Koenigsberg, PW Barone… - Biomaterials, 2022 - Elsevier
Food systems of the future will need to face an increasingly clear reality–that a protein-rich
diet is essential for good health, but traditional meat products will not suffice to ensure safety …

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

X Hu, Z Xia, K Cai - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Mesenchymal stem cells (MSCs) have been increasingly recognized as a resource for
disease treatment and regenerative medicine. Meanwhile, the unique chemical and physical …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

Cultivating multidisciplinarity: Manufacturing and sensing challenges in cultured meat production

M Djisalov, T Knežić, I Podunavac, K Živojević… - Biology, 2021 - mdpi.com
Simple Summary United Nations estimates that by the year 2050, the population of nearly 10
billion people will have 70% higher food demands than the current food systems can …

[HTML][HTML] Recent advances in bioreactors for cell-based therapies

M Stephenson, W Grayson - F1000Research, 2018 - ncbi.nlm.nih.gov
Bioreactors have become indispensable tools in the cell-based therapy industry. Various
forms of bioreactors are used to maintain well-controlled microenvironments to regulate cell …

The importance of proper oxygenation in 3D culture

HM Tse, G Gardner, J Dominguez-Bendala… - … in bioengineering and …, 2021 - frontiersin.org
Cell culture typically employs inexpensive, disposable plasticware, and standard humidified
CO2/room air incubators (5% CO2,∼ 20% oxygen). These methods have historically proven …

Scaling up human mesenchymal stem cell manufacturing using bioreactors for clinical uses

MG Jankovic, M Stojkovic, S Bojic, N Jovicic… - Current Research in …, 2023 - Elsevier
Human mesenchymal stem cells (hMSCs) are multipotent cells and an attractive therapeutic
agent in regenerative medicine and intensive clinical research. Despite the great potential …