Neutrophils (also called polymorphonuclear leukocytes) are the most abundant leukocytes
whose primary purpose as anti-microbial professional phagocytes is to kill extracellular …

Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder, characterized by
diffuse palmoplantar keratoderma and precocious aggressive periodontitis, leading to …

Lysosomal cathepsins are proteolytic enzymes increasingly recognized as prognostic
markers and potential therapeutic targets in a variety of diseases. In those conditions, the …

The Papillon-Lefevre syndrome (PLS) was first described by Papillon and Lefevre in 1924. It
is an autosomal recessive disorder characterized by a diffuse palmoplanter hyperkeratosis …

Papillon–Lefèvre syndrome (PLS; OMIM 245000) is an autosomal recessive condition
characterized by palmoplantar hyperkeratosis and periodontitis. In 1997, the gene locus for …

The article presents various forms of Mendelian genetic diseases with associated
periodontitis. These include neutrophil disorders, inherited neutropenias and type1 and type …

Background Loss-of-function point mutations in the cathepsin C gene are the underlying
genetic event in patients with Papillon-Lefèvre syndrome (PLS). PLS neutrophils lack serine …

Aim. This paper revisits Papillon‐Lefèvre syndrome (PLS), addresses its diagnostic update
and dental management, and reports a case of a 5‐year‐old Lebanese patient with …

Abstract Aim: The autosomal‐recessive Papillon–Lefèvre syndrome (PLS) is characterized
by severe aggressive periodontitis, combined with palmoplantar hyperkeratosis, and is …

PURPOSE: Papillon-Lefèvre syndrome is a rare autosomal recessive genetic disorder
characterized by palmar-plantar hyperkeratosis, with rapidly progressive periodontitis and …