Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

The multi-dimensional challenge of drug resistance is one of the pivotal hindrances for
cancer chemotherapy. A reductive approach to define and distinguish the main aspects of …

Natural selection can only operate on available genetic variation. Thus, determining the
probability of accessing different sequence variants from a starting sequence can help …

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …

Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational
biases that influence genome evolution and adaptation. How do such diverse biases …

We need novel strategies to target the complexity of cancer and, particularly, of metastatic
disease. As an example of this complexity, certain tissues are particularly hospitable …

The joint distribution of selection coefficients and mutation rates is a key determinant of the
genetic architecture of molecular adaptation. Three different distributions are of immediate …

Bcr-Abl1 kinase domain mutations are the most prevalent cause of treatment resistance in
chronic myeloid leukaemia (CML). Alternate resistance pathways nevertheless exist, and …

Introduction: Photothermal responsive, antimicrobial hydrogels are very attractive and have
great potential in the field of tissue engineering. The defective wound environment and …

Bacterial plasmids play a fundamental role in antibiotic resistance. However, a lack of
knowledge about their biology is an obstacle in fully understanding the mechanisms and …