Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …

Single-cell transcriptional profiling has rapidly advanced our understanding of the
embryonic hematopoiesis; however, whether and what role RNA alternative splicing (AS) …

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the
main embryonic arteries. The onset of circulation triggers several processes that provide …

The current paradigm that a single long-term hematopoietic stem cell can regenerate all
components of the mammalian immune system has been challenged by recent findings in …

Hematopoietic stem cells (HSCs) are a rare type of hematopoietic cell that can entirely
reconstitute the blood and immune system after transplantation. Allogeneic HSC …

Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central
role in blood cell production in adulthood. For many years it was assumed that these roles …

Our knowledge of the complexity of the developing hematopoietic system has dramatically
expanded over the course of the last few decades. We now know that, while hematopoietic …

Hematopoietic stem cells (HSCs) are derived from hemogenic endothelial cells (HECs)
during embryogenesis. The HSC-primed HECs increased to the peak at embryonic day (E) …