The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

We show that the time required to transcribe human genes larger than 800 kb spans more
than one complete cell cycle, while their transcription speed equals that of smaller genes …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

DNA replication is highly regulated, ensuring faithful inheritance of genetic information
through each cell cycle. In metazoans, this process is initiated at many thousands of DNA …

Faithful transmission of genetic material to daughter cells involves a characteristic temporal
order of DNA replication, which may play a significant role in the inheritance of epigenetic …

DNA replication is central to cell proliferation. Studies in the past six decades since the
proposal of a semiconservative mode of DNA replication have confirmed the high degree of …

At each cell division in humans, 30,000–50,000 DNA replication origins are activated, and it
remains unclear how they are selected and recognized by replication factors. DNA …

In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle.
Their genomic organization and their genetic nature remain elusive. Here, we characterized …