Cardiac involvement has a profound effect on the prognosis of patients with systemic
amyloidosis. Therapeutic methods for suppressing the production of causative proteins have …

The hypertrophic cardiomyopathy phenotype encompasses a heterogeneous spectrum of
genetic and acquired diseases characterized by the presence of left ventricular hypertrophy …

The mechanisms of tissue damage in kidney amyloidosis are not well described. To
investigate this further, we used laser microdissection-mass spectrometry to identify proteins …

Monoclonal immunoglobulin (Ig) light chain amyloidosis (AL) is a rare but severe disease
that may occur when a B or plasma cell clone secretes an excess of free Ig light chains …

Background In vivo mechanisms of amyloid clearance and cardiac tissue damage in cardiac
amyloidosis are not well understood. Objectives We aimed to define and quantify the …

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of
antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem …

Amyloidosis refers to a group of diseases caused by extracellular deposits of misfolded
proteins, which alter tissue function and structure, potentially affecting any organ. The term …

The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and
organ dysfunction. Clinical and experimental advances have cast new light on the …

Background/Aim: About 40% of patients with diffuse large cell lymphoma (DLBCL) still have
a poor prognosis. Additionally, DLBCL patients treated with doxorubicin are at risk of cardiac …

The term cardiac amyloidosis (CA) refers to the accumulation of extracellular amyloid
deposits in the heart because of different conditions often affecting multiple organs including …