Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic …
M Hao, J Gong, X Zeng, C Liu, Y Guo, X Cheng… - Nature …, 2024 - nature.com
Large pretrained models have become foundation models leading to breakthroughs in natural language processing and related fields. Developing foundation models for …
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …
Cancer is a devastating disease that alters the metabolism of a cell and the surrounding milieu. Metabolomics is a growing and powerful technology capable of detecting hundreds …
Different studies corroborate a role for ceramide synthases and their downstream products, ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …
T Kallunki, OD Olsen, M Jäättelä - Oncogene, 2013 - nature.com
Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal function. Accordingly, transformation and cancer progression are characterized by dramatic …
HJ Cho, HY Yoon, H Koo, SH Ko, JS Shim, JH Lee… - Biomaterials, 2011 - Elsevier
Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for intravenous docetaxel (DCT) delivery. In this study, physicochemical properties, cellular …
SM Pitson - Trends in biochemical sciences, 2011 - cell.com
Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation …
Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis, prognosis, treatment response, and personalized medicine. They serve as objective …