The establishment of a specific nucleoprotein structure, the telomere, is required to ensure
the protection of chromosome ends from being recognized as DNA damage sites. Telomere …

The six-subunit shelterin complex binds to mammalian telomeres and protects them from
triggering multiple DNA damage response pathways. The loss of this protective function by …

Higher-order architectures of chromosomes play important roles in the regulation of genome
functions. To understand the molecular mechanism of genome packing, an in vitro chromatin …

Eukaryotic DNA is packaged into nucleosomes, which further condenses into chromosomes.
The telomeres, which form the protective end-capping of chromosomes, play a pivotal role in …

In eukaryotes, the genome is packed into chromosomes, each consisting of large polymeric
fibers made of DNA bound with proteins (mainly histones) and RNA molecules. The nature …

Dinoflagellate birefringent chromosomes (BfCs) contain some of the largest known
genomes, yet they lack typical nucleosomal micrococcal-nuclease protection patterns …

Telomeric chromatin has peculiar features with respect to bulk chromatin, which are not fully
clarified to date. Nucleosomal arrays, reconstituted on fragments of human telomeric DNA …

The folding of the nucleosome array into a chromatin fiber modulates DNA accessibility and
is therefore an important factor for the control of gene expression. The statistical analysis of …

Characteristic steps during cellular apoptosis are the induction of chromatin condensation
and subsequent DNA fragmentation, finally leading to the formation of oligomers of …

A thorough understanding of electrostatic, elastic and topological behaviour of DNA has
provided some relevant mechanistic insights into the regulation of genetic expression …