Background Prenatal and perinatal insults are implicated in the aetiopathogenesis of
psychotic disorders but the consistency and magnitude of their associations with psychosis …

The fields of psychiatry and mental health are increasingly recognizing the importance of
social determinants of health (SDOH) and their impact on mental health outcomes. In this …

Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum
disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

The heterogeneity in recovery outcomes for individuals with First Episode Psychosis (FEP)
calls for a strong evidence base to inform practice at an individual level. Between 19–89% of …

Introduction More than a century of research on the neurobiological underpinnings of major
psychiatric disorders (major depressive disorder [MDD], bipolar disorder [BD], schizophrenia …

Seduced by their mathematical beauty, psychologists have been using latent variable
models for more than a century. Whether discussing a general factor of cognitive ability …

Ursini et al reported recently that the liability of schizophrenia explained by a polygenic risk
score (PRS) derived from the variants most associated with schizophrenia was increased 5 …

Gene–environment (GxE) interactions have been related to psychosis spectrum disorders,
involving multiple common genetic variants in multiple genes with very small effect sizes …

To understand the role of environment in the pathoetiology of psychosis spectrum disorders,
research has thus far mainly investigated the effects of single exposures in isolation, such as …