Epidermal growth factor receptor‐2 (HER‐2) is overexpressed in 20 to 25% of human breast
cancers, which is associated with aggressive tumour growth and poor prognosis …

Trastuzumab (Herceptin®) is a humanised monoclonal antibody used in the treatment of
breast cancer that overexpresses human epidermal growth factor receptor 2 (HER2), which …

Poly (amidoamine)(PAMAM) dendrimer-based multifunctional cancer therapeutic
conjugates have been designed and synthesized. The primary amino groups on the surface …

Background. A higher incidence of central nervous system (CNS) metastases in HER-2–
positive metastatic breast cancer (MBC) has recently been reported. Materials and Methods …

Abstract Background A randomized Phase II study evaluated the activity of weekly paclitaxel
versus its combination with trastuzumab for treatment of patients with advanced breast …

Background: Paclitaxel and docetaxel are considered fundamental drugs in the treatment of
breast cancer. Objectives: To review the current role of taxanes in the treatment breast …

Background:: Metronomic chemotherapy—the chronic administration of chemotherapy at
relatively low, minimally toxic doses on a frequent schedule of administration at close …

Abstract Learning Objectives After completing this course, the reader will be able to:
Evaluate the results of trials assessing the efficacy of monotherapy and doublet therapy of …

Trastuzumab is a recombinant humanized monoclonal antibody used for the treatment of
advanced breast cancer. It improves survival and increases response to chemotherapy. The …

Abstract Learning Objectives After completing this course, the reader will be able to: Identify
the response rates to weekly paclitaxel and docetaxel for metastatic breast cancer. Name …