Rhabdomyosarcoma
SX Skapek, A Ferrari, AA Gupta, PJ Lupo… - Nature reviews disease …, 2019 - nature.com
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
Current and future treatment strategies for rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
Therapeutic approaches targeting PAX3-FOXO1 and its regulatory and transcriptional pathways in rhabdomyosarcoma
TH Nguyen, FG Barr - Molecules, 2018 - mdpi.com
Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal
muscle lineage and predominantly occur in children and young adults. A specific …
muscle lineage and predominantly occur in children and young adults. A specific …
Aurora A kinase inhibition destabilizes PAX3-FOXO1 and MYCN and synergizes with navitoclax to induce rhabdomyosarcoma cell death
J Ommer, JL Selfe, M Wachtel, EM O'Brien… - Cancer research, 2020 - AACR
The clinically aggressive alveolar rhabdomyosarcoma (RMS) subtype is characterized by
expression of the oncogenic fusion protein PAX3-FOXO1, which is critical for tumorigenesis …
expression of the oncogenic fusion protein PAX3-FOXO1, which is critical for tumorigenesis …
[HTML][HTML] PAX3-FOXO1: Zooming in on an “undruggable” target
M Wachtel, BW Schäfer - Seminars in cancer biology, 2018 - Elsevier
Driver oncogenes are prime targets for therapy in tumors many of which, including
leukemias and sarcomas, express recurrent fusion transcription factors. One specific …
leukemias and sarcomas, express recurrent fusion transcription factors. One specific …
Combinatorial strategies to potentiate the efficacy of HDAC inhibitors in fusion-positive sarcomas
C Lanzi, G Cassinelli - Biochemical Pharmacology, 2022 - Elsevier
Fusion positive (FP) sarcomas are characterized by chromosomal rearrangements
generating pathognomonic fusion transcripts and oncoproteins. In Ewing's sarcoma family of …
generating pathognomonic fusion transcripts and oncoproteins. In Ewing's sarcoma family of …
Epigenetic regulation of the PTEN–AKT–RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma
Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with poor prognosis.
As transient and stable modifications to chromatin have emerged as critical mechanisms in …
As transient and stable modifications to chromatin have emerged as critical mechanisms in …
[HTML][HTML] Genetics, epigenetics and redox homeostasis in rhabdomyosarcoma: Emerging targets and therapeutics
A Pal, HY Chiu, R Taneja - Redox Biology, 2019 - Elsevier
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma accounting for 5–8% of
malignant tumours in children and adolescents. Children with high risk disease have poor …
malignant tumours in children and adolescents. Children with high risk disease have poor …
Genomic and epigenetic changes drive aberrant skeletal muscle differentiation in rhabdomyosarcoma
S Pomella, SG Danielli, R Alaggio, WB Breunis… - Cancers, 2023 - mdpi.com
Simple Summary Rhabdomyosarcoma is the most common soft tissue cancer in children
and adolescents. Its resemblance to skeletal muscle tissue distinguishes …
and adolescents. Its resemblance to skeletal muscle tissue distinguishes …
Molecular and cellular changes during cancer progression resulting from genetic and epigenetic alterations
K Pruitt - Progress in Molecular Biology and Translational …, 2016 - Elsevier
Tumorigenesis is a complex process that involves a persistent dismantling of cellular
safeguards and checkpoints. These molecular and cellular changes that accumulate over …
safeguards and checkpoints. These molecular and cellular changes that accumulate over …