Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Regulation of gene expression by cis-acting long non-coding RNAs

N Gil, I Ulitsky - Nature Reviews Genetics, 2020 - nature.com
Long non-coding RNAs (lncRNAs) are diverse transcription products emanating from
thousands of loci in mammalian genomes. Cis-acting lncRNAs, which constitute a …

Functional long non-coding RNAs evolve from junk transcripts

AF Palazzo, EV Koonin - Cell, 2020 - cell.com
Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Long noncoding RNAs: molecular modalities to organismal functions

JL Rinn, HY Chang - Annual review of biochemistry, 2020 - annualreviews.org
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …

Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex

B Zuckerman, M Ron, M Mikl, E Segal, I Ulitsky - Molecular Cell, 2020 - cell.com
The core components of the nuclear RNA export pathway are thought to be required for
export of virtually all polyadenylated RNAs. Here, we depleted different proteins that act in …

Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

A Zhao, H Zhou, J Yang, M Li, T Niu - Signal Transduction and Targeted …, 2023 - nature.com
Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Mechanisms of long noncoding RNA nuclear retention

CJ Guo, G Xu, LL Chen - Trends in biochemical sciences, 2020 - cell.com
Long noncoding RNAs (lncRNAs) are crucial regulators in diverse cellular contexts and
biological processes. The subcellular localization of lncRNAs determines their modes of …

Context-specific effects of sequence elements on subcellular localization of linear and circular RNAs

M Ron, I Ulitsky - Nature communications, 2022 - nature.com
Long RNAs vary extensively in their post-transcriptional fates, and this variation is attributed
in part to short sequence elements. We used massively parallel RNA assays to study how …