HIV treatment and prevention 2019: current standards of care

N Phanuphak, RM Gulick - Current Opinion in HIV and AIDS, 2020 - journals.lww.com
HIV treatment and prevention 2019: current standards of care : Current Opinion in HIV and
AIDS HIV treatment and prevention 2019: current standards of care : Current Opinion in HIV …

Two‐drug vs. three‐drug combinations for HIV‐1: Do we have enough data to make the switch?

S Moreno, CF Perno, PW Mallon, G Behrens… - HIV …, 2019 - Wiley Online Library
Three‐drug combination antiretroviral therapy (ART) became available in 1996, dramatically
improving the prognosis of people living with HIV. The clinical benefits of ART are due to the …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2018 recommendations of the International Antiviral Society–USA Panel

MS Saag, CA Benson, RT Gandhi, JF Hoy… - Jama, 2018 - jamanetwork.com
Importance Antiretroviral therapy (ART) is the cornerstone of prevention and management of
HIV infection. Objective To evaluate new data and treatments and incorporate this …

Efficacy and safety of dolutegravir–rilpivirine for maintenance of virological suppression in adults with HIV-1: 100-week data from the randomised, open-label, phase 3 …

M Aboud, C Orkin, D Podzamczer, JR Bogner… - The lancet HIV, 2019 - thelancet.com
Background Primary analyses of the SWORD-1 and SWORD-2 trials at 48 weeks showed
that switching to a two-drug regimen of dolutegravir plus rilpivirine was non-inferior to …

Dolutegravir plus lamivudine maintains human immunodeficiency virus-1 suppression through week 48 in a pilot randomized trial

BO Taiwo, VC Marconi, B Berzins… - Clinical Infectious …, 2018 - academic.oup.com
In this randomized pilot clinical trial, dolutegravir plus lamivudine was noninferior to
continuation of standard 3-drug maintenance antiretroviral therapy. There was no …

A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non …

R Landman, P de Truchis, L Assoumou, S Lambert… - The Lancet …, 2022 - thelancet.com
Background Intermittent (on 4 days per week) antiretroviral therapy (ART) for patients with
HIV-1 might be more convenient, better tolerated, and cheaper than continuous treatment …

Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA) …

NI Paton, J Musaazi, C Kityo, S Walimbwa, A Hoppe… - The Lancet …, 2022 - thelancet.com
Background WHO guidelines recommend dolutegravir plus two nucleoside reverse
transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first …

Two-drug regimens for HIV treatment

KM Gibas, SG Kelly, JR Arribas, P Cahn, C Orkin… - The Lancet …, 2022 - thelancet.com
Combination therapy with three antiretroviral agents has been integral to successful HIV-1
treatment since 1996. Although the efficacy, adverse effects, and toxicities of contemporary …

DOLAMA study: effectiveness, safety and pharmacoeconomic analysis of dual therapy with dolutegravir and lamivudine in virologically suppressed HIV-1 patients

C Hidalgo-Tenorio, LL Cortés, A Gutiérrez, J Santos… - Medicine, 2019 - journals.lww.com
Dolutegravir (DTG) has shown effectiveness in combination with rilpivirine in with
experience of antiretroviral therapy (ART) and with 3TC in naïve patients (GEMINI trial). The …

Impact of the M184V resistance mutation on virological efficacy and durability of lamivudine-based dual antiretroviral regimens as maintenance therapy in individuals …

R Gagliardini, A Ciccullo, A Borghetti… - Open forum …, 2018 - academic.oup.com
Background Dual therapy (DT) with boosted protease inhibitors (bPIs) plus lamivudine has
been shown to be superior to bPI monotherapy in virologically suppressed patients despite …