The human obesity gene map: the 2005 update

T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel… - …, 2006 - Wiley Online Library
This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

VPAC and PAC receptors: from ligands to function

L Dickson, K Finlayson - Pharmacology & therapeutics, 2009 - Elsevier
Vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase activating
polypeptides (PACAPs) share 68% identity at the amino acid level and belong to the …

[HTML][HTML] Role of PACAP in migraine: An alternative to CGRP?

S Guo, I Jansen-Olesen, J Olesen… - Neurobiology of Disease, 2023 - Elsevier
Migraine is a widespread and debilitating neurological condition affecting more than a
billion people worldwide. Thus, more effective migraine therapies are highly needed. In the …

[HTML][HTML] Trends of nanotechnology in type 2 diabetes mellitus treatment

YV Simos, K Spyrou, M Patila, N Karouta… - Asian journal of …, 2021 - Elsevier
There are several therapeutic approaches in type 2 diabetes mellitus (T2DM). When diet
and exercise fail to control hyperglycemia, patients are forced to start therapy with …

Discovery of PACAP and its receptors in the brain

T Hirabayashi, T Nakamachi, S Shioda - The journal of headache and pain, 2018 - Springer
Pituitary adenylate-cyclase-activating polypeptide (PACAP) is a 27-or 38-amino acid
neuropeptide, which belongs to the vasoactive intestinal polypeptide (VIP)/glucagon …

The human obesity gene map: the 2004 update

L Pérusse, T Rankinen, A Zuberi, YC Chagnon… - Obesity …, 2005 - Wiley Online Library
This paper presents the eleventh update of the human obesity gene map, which
incorporates published results up to the end of October 2004. Evidence from single‐gene …

The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase-activating polypeptide-(1–38)

L Zhu, C Tamvakopoulos, D Xie, J Dragovic… - Journal of Biological …, 2003 - ASBMB
Dipeptidyl peptidase IV (DP-IV) is a cell surface serine dipeptidase that is involved in the
regulation of the incretin hormones, glucagon-like peptide (GLP-1) and glucose-dependent …

Hypothalamic control of energy metabolism via the autonomic nervous system

A Kalsbeek, E Bruinstroop, CX Yi… - Annals of the New …, 2010 - Wiley Online Library
The hypothalamic control of hepatic glucose production is an evident aspect of energy
homeostasis. In addition to the control of glucose metabolism by the circadian timing system …

Distribution of vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide receptors (VPAC1, VPAC2, and PAC1 receptor) in the rat brain

KM Joo, YH Chung, MK Kim, RH Nam… - Journal of …, 2004 - Wiley Online Library
To examine the distributions of VIP/PACAP receptors (VPAC1, VPAC2, and PAC1 receptors)
in the brain and to identify the cell types that express these receptors, we performed …

Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide

A Somogyvari-Vigh, D Reglodi - Current pharmaceutical design, 2004 - ingentaconnect.com
Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …