Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

The most significant advance in the medical management of HIV-1 infection has been the
treatment of patients with antiviral drugs, which can suppress HIV-1 replication to …

Inhibition of the chemokine receptor CXCR4 in combination with blockade of the PD-1/PD-
L1 T cell checkpoint induces T cell infiltration and anticancer responses in murine and …

Evidence suggests that the CXC–chemokine receptor-4 pathway plays a role in cancer cell
homing and metastasis, and thus represents a potential target for cancer therapy. The …

Signals from the microenvironment have a profound influence on the maintenance and/or
progression of hematopoietic and epithelial cancers. Mesenchymal or marrow-derived …

Over the last decade, the active role of the microenvironment in the pathogenesis of B cell
lymphomas has been recognized, delivering signals that favor clonal expansion and drug …

The bone marrow is the site of neutrophil production, a process that is regulated by the
cytokine granulocyte colony‐stimulating factor (G‐CSF). Mature neutrophils are continually …

Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …

Hematopoietic and epithelial cancer cells express CXCR4, a seven-transmembrane G-
protein-coupled chemokine receptor. Stromal cells within the bone marrow …

Hematopoietic progenitor cells (HPCs) traffic to and are retained in the marrow through the
trophic effects of the chemokine stromal cell-derived factor-1α (SDF-1α) binding to its …