Biomaterials, biomedical devices and engineered cell grafts can be implanted to restitute
tissue anatomy and function. Such implants can either integrate physiologically, with no or …

Fluorescence microscopy, in particular immunofluorescence microscopy, has been used
extensively for the assessment of kidney function and pathology for both research and …

Tissue regeneration is limited in several organs, including the kidney, contributing to the
high prevalence of kidney disease globally. However, evolutionary and physiological …

Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the
underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely …

Human islet transplantations into rodent models are an essential tool to aid in the
development and testing of islet and cellular-based therapies for diabetes prevention and …

Severe renal ischemia-reperfusion injury (IRI) can lead to acute and chronic kidney
dysfunction. Cytoskeletal modifications are among the main effects of this condition. The …

Chronic kidney disease (CKD) affects 8–16% of the population worldwide and is
characterized by fibrotic processes. Understanding the cellular and molecular mechanisms …

Although macula densa (MD) cells are chief regulatory cells in the nephron with unique
microanatomical features, they have been difficult to study in full detail due to their …

Alport syndrome (AS) is a genetic disorder caused by mutations in type IV collagen that lead
to defective glomerular basement membrane, glomerular filtration barrier (GFB) damage …

Serial intravital 2-photon microscopy of the kidney and other abdominal organs is a powerful
technique to assess tissue function and structure simultaneously and over time. Thus, serial …