[HTML][HTML] Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence …
BACKGROUND Hepatitis C virus genotype 3a (HCV G3a) is highly prevalent in Pakistan.
Due to the elevated cost of available Food and Drug Administration-approved drugs against …
Due to the elevated cost of available Food and Drug Administration-approved drugs against …
Characterization of interactions between hepatitis C virus NS5B polymerase, annexin A2 and RNA–effects on NS5B catalysis and allosteric inhibition
SMØ Solbak, E Abdurakhmanov, A Vedeler… - Virology journal, 2017 - Springer
Abstract Background Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV)
therapy and clearance for a majority of patients, but are not available or effective for all …
therapy and clearance for a majority of patients, but are not available or effective for all …
Hesperidin identified from Citrus extracts potently inhibits HCV genotype 3a NS3 protease
Background Hepatitis C virus infection is the main cause of liver ailments across the globe.
Several HCV genotypes have been identified in different parts of the world. Effective drugs …
Several HCV genotypes have been identified in different parts of the world. Effective drugs …
The Q41R mutation in the HCV-protease enhances the reactivity towards MAVS by suppressing non-reactive pathways
C Zheng, M Schneider, A Marion, I Antes - … Chemistry Chemical Physics, 2022 - pubs.rsc.org
Recent experimental findings pointed out a new mutation in the HCV protease, Q41R,
responsible for a significant enhancement of the enzyme's reactivity towards the …
responsible for a significant enhancement of the enzyme's reactivity towards the …
Biophysical mode-of-action and selectivity analysis of Allosteric inhibitors of hepatitis C virus (HCV) polymerase
E Abdurakhmanov, S Øie Solbak, UH Danielson - Viruses, 2017 - mdpi.com
Allosteric inhibitors of hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase
are effective for treatment of genotype 1, although their mode of action and potential to …
are effective for treatment of genotype 1, although their mode of action and potential to …
HCV resistance-associated substitutions following direct-acting antiviral therapy failure–Real-life data from Poland
M Parczewski, E Janczewska, A Pisula… - Infection, Genetics and …, 2021 - Elsevier
Background This study analysed the NS3 and NS5A mutation frequencies, persistence and
drug susceptibility in a cohort of real-life patients, with failed hepatitis C virus (HCV) therapy …
drug susceptibility in a cohort of real-life patients, with failed hepatitis C virus (HCV) therapy …
Application of QM/MM methods to Protein/Ligand binding
C Zheng - 2022 - mediatum.ub.tum.de
Serine proteases are one type of enzymes that are able to cleave peptide bonds in proteins,
in which serine serves as a nucleophile at the active site. Because of the important …
in which serine serves as a nucleophile at the active site. Because of the important …
[HTML][HTML] Cl-amidine chemical
M Parczewski, E Janczewska, A Pisula, D Dybowska… - cl-amidinechemical.com
Background: This study analysed the NS3 and NS5A mutation frequencies, persistence and
drug susceptibility in a cohort of real-life patients, with failed hepatitis C virus (HCV) therapy …
drug susceptibility in a cohort of real-life patients, with failed hepatitis C virus (HCV) therapy …
Molecular interaction analysis for discovery of drugs targeting enzymes and for resolving biological function
UH Danielson - Multifaceted Roles of Crystallography in Modern Drug …, 2015 - Springer
Abstract Analysis of molecular interactions using surface plasmon resonance (SPR)
biosensor technology has become a powerful tool for discovery of drugs targeting enzymes …
biosensor technology has become a powerful tool for discovery of drugs targeting enzymes …
Identification of weak points of hepatitis C virus NS3 protease inhibitors using surface plasmon resonance biosensor-based interaction kinetic analysis and genetic …
S Svahn Gustafsson, A Ehrenberg… - Journal of Medicinal …, 2014 - ACS Publications
To aid the design of next generation hepatitis C virus (HCV) drugs, the kinetics of the
interactions between NS3 protease inhibitors and enzyme from genotypes 1a, 1b, and 3a …
interactions between NS3 protease inhibitors and enzyme from genotypes 1a, 1b, and 3a …