Epigenetics including DNA and RNA modifications have always been the hotspot field of life
sciences in the post-genome era. Since the first mapping of N6-methyladenosine (m6A) and …

MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene
expression post-transcriptionally. These non-coding regulatory RNAs become functional …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

Bisulfite sequencing (BS-seq) to detect 5-methylcytosine (5mC) is limited by lengthy reaction
times, severe DNA damage, overestimation of 5mC level and incomplete C-to-U conversion …

Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …

Circular (circ) RNAs have emerged as novel regulators of gene expression through various
mechanisms. However, most publications focus on functional circRNAs regulating target …

Abstract Epigenetic (“above genetics”) modifications can alter the gene expression without
altering the DNA sequence. Aberrant epigenetic regulations in cancer include DNA …

Ribonuclease (RNA) modifications can alter cellular function and lead to differential immune
responses by acting as discriminators between RNAs from different phyla. RNA …

As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA
modification processes have been reported, and they are widely present in every organism …

The ALYREF protein acts as a crucial epigenetic regulator in several cancers. However, the
specific expression levels and functional roles of ALYREF in cancers are largely unknown …