Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Tools for mammalian glycoscience research

ME Griffin, LC Hsieh-Wilson - Cell, 2022 - cell.com
Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Y Xu, T Li, Z Zhou, J Hong, Y Chao, Z Zhu… - Nature …, 2023 - nature.com
Many eukaryotic receptors and enzymes rely on glycosylphosphatidylinositol (GPI) anchors
for membrane localization and function. The transmembrane complex GPI-T recognizes …

Accumulated precursors of specific GPI-anchored proteins upregulate GPI biosynthesis with ARV1

YS Liu, Y Wang, X Zhou, L Zhang, G Yang… - Journal of Cell …, 2023 - rupress.org
We previously reported that glycosylphosphatidylinositol (GPI) biosynthesis is upregulated
when endoplasmic reticulum–associated degradation (ERAD) is defective; however, the …

Bacterial pore-forming toxins

FR Ulhuq, G Mariano - Microbiology, 2022 - microbiologyresearch.org
Pore-forming toxins (PFTs) are widely distributed in both Gram-negative and Gram-positive
bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host …

CircRNAs regulate the crosstalk between inflammation and tumorigenesis: the bilateral association and molecular mechanisms

J Qadir, S Wen, H Yuan, BB Yang - Molecular Therapy, 2023 - cell.com
Inflammation, a hallmark of cancer, has been associated with tumor progression, transition
into malignant phenotype and efficacy of the chemotherapeutic agents in cancer. Chronic …

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum

MS Bulloch, LK Huynh, K Kennedy, JE Ralton… - PLoS …, 2024 - journals.plos.org
Glycophosphatidylinositol (GPI) anchors are the predominant glycoconjugate in
Plasmodium parasites, enabling modified proteins to associate with biological membranes …

(Patho) physiology of glycosylphosphatidylinositol-anchored proteins I: Localization at plasma membranes and extracellular compartments

GA Müller, TD Müller - Biomolecules, 2023 - mdpi.com
Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of plasma membranes (PMs) of all eukaryotic organisms studied so far by covalent linkage …

Mining the Penicillium expansum Genome for Virulence Genes: A Functional-Based Approach to Discover Novel Loci Mediating Blue Mold Decay of Apple Fruit

D Luciano-Rosario, H Peng, VL Gaskins, JM Fonseca… - Journal of Fungi, 2023 - mdpi.com
Blue mold, a postharvest disease of pome fruits, is caused by the filamentous fungus
Penicillium expansum. In addition to the economic losses caused by P. expansum, food …

Zinc transport via ZNT5-6 and ZNT7 is critical for cell surface glycosylphosphatidylinositol-anchored protein expression

T Wagatsuma, K Shimotsuma, A Sogo, R Sato… - Journal of Biological …, 2022 - ASBMB
Glycosylphosphatidylinositol (GPI)-anchored proteins play crucial roles in various enzyme
activities, cell signaling and adhesion, and immune responses. While the molecular …