[HTML][HTML] Stress-induced senescence in mesenchymal stem cells: Triggers, hallmarks, and current rejuvenation approaches

SS Lee, TT Vũ, AS Weiss, GC Yeo - European Journal of Cell Biology, 2023 - Elsevier
Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the
treatment of degenerative and inflammatory conditions. However, despite accumulating …

Scaling up stem cell production: harnessing the potential of microfluidic devices

L Ding, S Oh, J Shrestha, A Lam, Y Wang… - Biotechnology …, 2023 - Elsevier
Stem cells are specialised cells characterised by their unique ability to both self-renew and
transform into a wide array of specialised cell types. The widespread interest in stem cells for …

Developing a far-red fluorogenic beta-galactosidase probe for senescent cell imaging and photoablation

SK Lee, Z Shen, MS Han, CH Tung - RSC advances, 2022 - pubs.rsc.org
A methylene blue (MB)-based beta-galactosidase (β-gal) activatable molecule, Gal-MB, was
developed for senescence imaging and light-triggered senolysis. When in contact with LacZ …

Targeted therapeutics delivery by exploiting biophysical properties of senescent cells

J Low, B Chan, A Tay - Advanced Functional Materials, 2022 - Wiley Online Library
Cellular senescence refers to a state of irreversible arrest of cell proliferation in response to
various forms of cellular stress. It is known that the accumulation of senescent cells is a …

Basic concepts of biological microparticles isolation by inertia spiral microchannels in simple terms: a review

SA Tabatabaei, MZ Targhi… - Journal of …, 2021 - iopscience.iop.org
The microfluidics separation has absorbed wide-ranging attention in recent years due to its
outstanding advantages in biological, medical, clinical, and diagnostical cell studies. While …

The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging

SS Lee, A Al Halawani, JD Teo, AS Weiss… - Advanced …, 2024 - Wiley Online Library
Cellular senescence leads to the functional decline of regenerative cells such as
mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and …

[HTML][HTML] Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside

Z Zou, X Luo, Z Chen, YS Zhang, C Wen - Theranostics, 2022 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a prevalent debilitating age-related joint degenerative disease. It is a
leading cause of pain and functional disability in older adults. Unfortunately, there is no cure …

Continuous Particle Separation Driven by 3D Ag-PDMS Electrodes with Dielectric Electrophoretic Force Coupled with Inertia Force

X Li, J Duan, Z Qu, J Wang, M Ji, B Zhang - Micromachines, 2022 - mdpi.com
Cell separation has become@ important in biological and medical applications.
Dielectrophoresis (DEP) is widely used due to the advantages it offers, such as the lack of a …

[图书][B] Applying microfluidics for industrial production of stem cells

L Ding - 2022 - search.proquest.com
Stem cells represent a cutting-edge technology with the potential to revolutionise both the
therapeutic and agricultural industries. They are cells which can renew themselves and …