Purinergic signaling has emerged as an important player in cancer progression and is
regulated by a series of nucleotidases. Among the enzyme cascade, CD73, which catelyzes …

CD73 is a novel immune checkpoint associated with adenosine metabolism that promotes
tumor progression by suppressing antitumor immune response and promoting …

Acute liver injury is characterized by fibrosis, inflammation and apoptosis, leading to liver
failure, cirrhosis or cancer and affecting the clinical outcome in the long term. However, no …

Recent studies have shown that the non-enzymatic function of CD73 plays a key role in
tumor progression, but this function of CD73 in pancreatic cancer cells has not been studied …

Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation
and an important factor for immune regulation. The purine de novo pathway and salvage …

Background CD73 has both enzymatic and non-enzymatic functions in cells. As a
nucleotidase, CD73 plays its enzymatic function by catalyzing the hydrolysis of AMP into …

CD73 is a cell surface immunosuppressive enzyme involved in tumor progression and
metastasis. While patients whose cancer cells express elevated CD73 are typically …

Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for
advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) …

Background Finding drugs that can interact with a specific target to induce a desired
therapeutic outcome is key deliverable in drug discovery for targeted treatment. Therefore …

Muscle development, or myogenesis, is a highly regulated, complex process. A subset of
microRNAs (miRNAs) have been identified as critical regulators of myogenesis. Recently …