Mitochondrial dynamics are regulated by two sets of opposed processes: mitochondrial
fusion and fission, and mitochondrial biogenesis and degradation (including mitophagy), as …

Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as
rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues …

The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune …

In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …

Aberrant induction of type I IFN is a hallmark of the inherited encephalopathy Aicardi-
Goutières syndrome (AGS), but the mechanisms triggering disease in the human central …

The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic
organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from …

Air pollution exerts several deleterious effects on the cardiovascular system, with
cardiovascular disease (CVD) accounting for 80% of all premature deaths caused by air …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Mitochondrial dysfunction is a key driver of inflammatory responses in human disease.
However, it remains unclear whether alterations in mitochondria-innate immune cross-talk …