In his seminal work, 1 Rolf Huisgen defined 1, 3-dipolar cycloadditions as “1, 3-Dipole, abc,
must be defined, such that atom a posseses an electron sextet, that is, an incomplete …

Reactions that utilize addition of active C− H nucleophiles to C X bonds represent some of
the most fundamental carbon− carbon bond-forming processes in organic chemistry. Of …

Comprehensive computational studies were carried out to explore the mechanisms of
enantioselective Cu/Pd and stereodivergent Cu/Ir dual-catalytic syntheses of α, α …

Restoration of p53 activity by inhibition of the p53–MDM2 interaction has been considered
an attractive approach for cancer treatment. However, the hydrophobic protein–protein …

The addition of a 1, 3-dipole to an alkene or alkyne is a prominent transformation in organic
synthesis. 1 Over the past two decades the intense study of enantioselective 1, 3-dipolar …

In biology-oriented synthesis the underlying scaffold classes of natural products selected in
evolution are used to define biologically relevant starting points in chemical structure space …

The synthetic strategies involving the construction and cleavage of a bond represent the
central theme in organic synthesis. The cleavage of a bond is achieved either by weakening …

The catalytic asymmetric 1, 3-dipolar cycloaddition of azomethine ylides constitutes one of
the most powerful and atom economical methods for the enantioselective construction of …

The success of phosphine-oxazoline ligands (PHOX) inspired the progress in P-oxazoline
ligand families by modifying either the ligand backbone, the electronic and/or steric …

The novel C 2-symmetric bis (imidazolidine) pyridine (PyBidine) ligand was easily
synthesized in a single condensation of 2, 6-pyridyl aldehyde and optically active (S, S) …