At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

The axon initial segment (AIS) is a critical microdomain for action potential initiation and
implicated in the regulation of neuronal excitability during activity-dependent plasticity. While …

The axon initial segment (AIS) is a critical compartment in neurons. It converts postsynaptic
input into action potentials that subsequently trigger information transfer to target neurons …

Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and
presynapses, but how membrane proteins are internalized along the axon shaft remains …

The axon initial segment (AIS) is the site of action potential generation and a locus of activity-
dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a …

The proteasome is essential for cellular responses to various physiological stressors.
However, how proteasome function impacts the stress resilience of regenerative damaged …

The rodent whisker-to-barrel cortex pathway is a classic model to study the effects of sensory
experience and deprivation on neuronal circuit formation, not only during development but …

Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability
to adapt action potential output to changes in network activity. Action potential initiation at …