Women are at twice the risk for anxiety and depression disorders as men are, although the
underlying biological factors and mechanisms are largely unknown. In this review, we …

Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

Chromatin is organized into multiscale three-dimensional structures, including chromosome
territories, A/B compartments, topologically associating domains, and chromatin loops. This …

The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …

Transcription factors (TFs) orchestrate gene expression programs crucial for brain function,
but we lack detailed information about TF binding in human brain tissue. We generated a …

After 60 years of chromatin investigation, our understanding of chromatin organization has
evolved from static chromatin fibers to dynamic nuclear compartmentalization. Chromatin is …

With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Schizophrenia is a chronic mental illness with a substantial genetic component. To unfold
the complex etiology of schizophrenia, it is important to understand the interplay between …

Schizophrenia pathogenesis remains challenging to define; however, there is strong
evidence that the interaction of genetic and environmental factors causes the disorder. This …

Schizophrenia is a highly heritable psychiatric disorder with a complex genetic risk
architecture that reflects the additive impact of hundreds of risk variants. While many …