Mechanism of arsenic carcinogenesis: an integrated approach

TG Rossman - … Research/Fundamental and Molecular Mechanisms of …, 2003 - Elsevier
Epidemiological evidence shows an association between inorganic arsenic in drinking
water and increased risk of skin, lung and bladder cancers. The lack of animal models has …

Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment

SM Cohen, LL Arnold, M Eldan, AS Lewis… - Critical reviews in …, 2006 - Taylor & Francis
Monomethylarsonic acid (MMA V) and dimethylarsinic acid (DMA V) are active ingredients in
pesticidal products used mainly for weed control. MMA V and DMA V are also metabolites of …

Arsenic in the aetiology of cancer

S Tapio, B Grosche - Mutation Research/Reviews in Mutation Research, 2006 - Elsevier
Arsenic, one of the most significant hazards in the environment affecting millions of people
around the world, is associated with several diseases including cancers of skin, lung, urinary …

Genotoxic and epigenetic mechanisms in arsenic carcinogenicity

E Bustaffa, A Stoccoro, F Bianchi, L Migliore - Archives of toxicology, 2014 - Springer
Arsenic is a human carcinogen with weak mutagenic properties that induces tumors through
mechanisms not yet completely understood. People worldwide are exposed to arsenic …

Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic

AS Andrew, JL Burgess, MM Meza… - Environmental …, 2006 - ehp.niehs.nih.gov
The mechanism (s) by which arsenic exposure contributes to human cancer risk is unknown;
however, several indirect cocarcinogenesis mechanisms have been proposed. Many …

Oral exposure to inorganic arsenic: evaluation of its carcinogenic and non-carcinogenic effects

U Schuhmacher–Wolz, HH Dieter, D Klein… - Critical reviews in …, 2009 - Taylor & Francis
Inorganic arsenic, which is extensively metabolised in humans into even more toxic
methylated arsenicals, is a potent carcinogen, causing tumours of the skin, lung, urinary …

Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells

E Dopp, LM Hartmann, AM Florea… - Toxicology and applied …, 2004 - Elsevier
Humans are exposed to arsenic and their organic derivatives, which are widely distributed in
the environment, via food, water, and to a lesser extent, via air. Following uptake, inorganic …

Environmental distribution, analysis, and toxicity of organometal (loid) compounds

E Dopp, LM Hartmann, AM Florea… - Critical reviews in …, 2004 - Taylor & Francis
The biochemical modification of the metals and metalloids mercury, tin, arsenic, antimony,
bismuth, selenium, and tellurium via formation of volatile metal hydrides and alkylated …

Effects of pesticides on human peripheral lymphocytes in vitro: induction of DNA damage

Ü Ündeğer, N Başaran - Archives of Toxicology, 2005 - Springer
Because of the widespread use of pesticides for domestic and industrial applications the
evaluation of their genotoxic effects is of major concern to public health. Although various …

Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA

T Schwerdtle, I Walter, I Mackiw, A Hartwig - Carcinogenesis, 2003 - academic.oup.com
Even though a well-known human carcinogen the underlying mechanisms of arsenic
carcinogenicity are still not fully understood. For arsenite, proposed mechanisms are the …