Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

Scarring and tissue fibrosis represent a significant source of morbidity in the United States.
Despite considerable research focused on elucidating the mechanisms underlying …

Aims More than 50% of patients with heart failure have preserved ejection fraction
characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Heart failure with preserved ejection fraction (HFpEF) constitutes a clinical syndrome in
which the diagnostic criteria of heart failure are not accompanied by gross disturbances of …

The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural
proteins, signaling molecules, and proteases. Changes in the overall integrity and …

Preclinical models of aortic stenosis can induce left ventricular pressure overload and
coarsely control the severity of aortic constriction. However, they do not recapitulate the …

Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic
tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis …

Preclinical large animal models of heart failure (HF) play a critical and expanding role in
translating basic science findings to the development and clinical approval of novel …

At least one-half of the growing heart failure population consists of heart failure with
preserved ejection fraction (HFpEF). The limited therapeutic options, the complexity of the …