Axial spondyloarthritis (axSpA) encompasses both radiographic and non-radiographic
axSpA. It is a chronic inflammatory disease with a predilection for involving the axial …

Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

Spondyloarthritis (SpA) is a chronic inflammatory disorder with high heritability but with
complex genetics. It encompasses several entities that share common clinical features. Most …

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease,
spondyloarthritis and psoriasis cause significant morbidity and are a considerable burden …

Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the most
prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These diseases share …

The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum
of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is …

Regulatory T cells (Tregs) are a very specialized subset of T lymphocytes: their main
function is controlling immune responses during inflammation. T-regs involvement in …

The axial SpAs (axSpAs) are clearly clinically a heterogeneous set of diseases with
markedly varying extra-articular features. These diseases are all highly heritable and have …

The number of people diagnosed with chronic inflammatory diseases has increased
noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD) …

Over the past decade, awareness of the importance of epigenetic alterations in the
pathogenesis of rheumatic diseases has grown in parallel with a general recognition of the …