Genetic methodologies are improving our understanding of the pathophysiology in diverse
diseases. Breakthroughs have been particularly impressive in nephrology, for which marked …

Renal disease in cocaine and heroin users is associated with the nephrotic syndrome, acute
glomerulonephritis, amyloidosis, interstitial nephritis, and rhabdomyolysis. The …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Background: The utility of whole-exome sequencing (WES) for the diagnosis and
management of adult-onset constitutional disorders has not been adequately studied …

Several lines of evidence point to kidney disease as an important complication of human
immunodeficiency virus (HIV) infection. Kidney function is abnormal in up to 30% of HIV …

Objective Immunosuppressive agents have become the standard of therapy for proliferative
lupus nephritis, but some patients may relapse after discontinuing treatment. We reviewed …

Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans
has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To …

Objective: to assess temporal changes in the incidence of human immunodeficiency virus-1-
associated nephropathy (HIVAN), and the association with use of highly active antiretroviral …

Background. Little is known about the racial differences in the incidence and progression of
HIV-related chronic kidney disease (CKD) that underlie African American—white disparities …

HIV infection is associated with several renal syndromes, including acute renal failure.
Chronic renal failure directly linked to HIV infection includes thrombotic microangiopathic …