Cognitive dysfunction with aging and the role of inflammation

AA Simen, KA Bordner, MP Martin… - … advances in chronic …, 2011 - journals.sagepub.com
As the average lifespan continues to climb because of advances in medical care, there is a
greater need to understand the factors that contribute to quality of life in the elderly. The …

Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes

I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

Plasma‐induced death of HepG2 cancer cells: intracellular effects of reactive species

X Yan, Z Xiong, F Zou, S Zhao, X Lu… - Plasma Processes …, 2012 - Wiley Online Library
Reports show that cold atmospheric‐pressure plasmas can induce death of cancer cells in
several minutes. However, very little is presently known about the mechanism of the plasma …

What animal models can tell us about long-term cognitive dysfunction following sepsis: a systematic review

FF Savi, A de Oliveira, GF de Medeiros… - Neuroscience & …, 2021 - Elsevier
Survivors of sepsis often develop long-term cognitive impairments. This review aimed at
exploring the results of the behavioral tools and tests which have been used to evaluate …

[HTML][HTML] Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-κB signaling

H Zhang, Z Wu, Y Yang, A Shaukat, J Yang… - Journal of Zhejiang …, 2019 - ncbi.nlm.nih.gov
Catalpol is the main active ingredient of an extract from Radix rehmanniae, which in a
previous study showed a protective effect against various types of tissue injury. However, a …

RhoA/ROCK-2 pathway inhibition and tight junction protein upregulation by catalpol suppresses lipopolysaccaride-induced disruption of blood-brain barrier …

S Feng, L Zou, H Wang, R He, K Liu, H Zhu - Molecules, 2018 - mdpi.com
Lipopolysaccaride (LPS) directly or indirectly injures brain microvascular endothelial cells
(BMECs) and damages the intercellular tight junction that gives rise to altered blood-brain …

Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells

H Hu, C Wang, Y Jin, Q Meng, Q Liu, Z Liu, K Liu, X Liu… - Inflammation, 2019 - Springer
Hyperhomocysteinemia (HHCY) has been recognized as an independent risk factor for
atherosclerosis and plays a vital role in the development of atherosclerosis. Catalpol, an …

Catalpol: a potential therapeutic for neurodegenerative diseases

B Jiang, RF Shen, J Bi, XS Tian… - Current Medicinal …, 2015 - ingentaconnect.com
Neurodegenerative disorders, eg, Alzheimer's disease (AD) and Parkinson's disease (PD)
are characterized by the progressive loss of neurons and subsequent cognitive decline …

Traditional Chinese medicine for senile dementia

Z Lin, J Gu, J Xiu, T Mi, J Dong… - … and Alternative Medicine, 2012 - Wiley Online Library
Traditional Chinese Medicine (TCM) has a 3000 years′ history of human use. A literature
survey addressing traditional evidence from human studies was done, with key result that …

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms

X Zhang, K Liu, M Shi, L Xie, M Deng, H Chen… - Brain Research Bulletin, 2021 - Elsevier
Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex
Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both …