Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …

The maturing mutational landscape of cancer genomes, the development and application of
clinical interventions and evolving insights into tumour-associated functions reveal …

We used established databases in standard ways to systematically characterize gene
ontologies, pathways and functional linkages in the large set of genes now associated with …

Cancer-associated adipocytes are known to cause inflammation; however, the role of
adipogenesis, the formation of adipocytes, in breast cancer is unclear. We hypothesized that …

The micro RNA (miR)-34 family is composed of 5p and 3p strands of miR-34a, miR-34b, and
miR-34c. The 5p strand's expression and function is studied in cervical cancer. The 3p …

Glucocorticoids (GCs), key mediators of stress signals, are also potent wound healing
inhibitors. To understand how stress signals inhibit wound healing, we investigated the role …

We have previously shown that general deletion of the gene encoding the p53-inducible
Mir34a microRNA enhances the number and invasion of colitis-associated colorectal …

Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen
receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified …

Protein kinase C (PKC) enzymes are a family of kinases that mediate signal transduction
originating at the cell surface. Most cell membranes can contain functional PKC enzymes …

The signaling mechanisms by which dietary fat and cholesterol signals regulate central
pathways of glucose homeostasis are not completely understood. By using a hepatocyte …