Veterinary ophthalmology in laboratory animal studies

RJ Munger - Veterinary ophthalmology, 2002 - Wiley Online Library
In this overview the current status of the role of veterinary ophthalmology in laboratory
animal studies is discussed. Attention is devoted to current regulatory requirements and …

Antioxidant supplementation increases retinal responses and decreases refractive error changes in dogs

W Wang, J Hernandez, C Moore, J Jackson… - Journal of nutritional …, 2016 - cambridge.org
The objective of the study was to examine whether a nutritional antioxidant supplementation
could improve visual function in healthy dogs as measured by electroretinography (ERG) …

Recommendations for a toxicological screening ERG procedure in laboratory animals

SG Rosolen, F Rigaudière, JFL Gargasson… - Documenta …, 2005 - Springer
Electroretinography, using laboratory animals, is a commonly used technique for
determining the retinal toxicity of chemical agents. In this paper, guidelines for performing …

Guidelines for clinical electroretinography in the dog: 2012 update

B Ekesten, AM Komáromy, R Ofri… - Documenta …, 2013 - Springer
The full-field, flash electroretinogram (ERG) is now a widely used test of canine retinal
function for the clinical diagnosis of hereditary retinal dystrophies and other causes of retinal …

Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid–rich fish …

SC Zicker, DE Jewell, RM Yamka… - Journal of the American …, 2012 - Am Vet Med Assoc
Objective—To assess effects of foods fortified with docosahexaenoic acid (DHA)–rich fish oil
on cognitive, memory, psychomotor, immunologic, and retinal function and other measures …

[图书][B] Toxicologic pathology: nonclinical safety assessment

PS Sahota, JA Popp, JF Hardisty, C Gopinath - 2013 - books.google.com
As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …

[HTML][HTML] Mutation discovered in a feline model of human congenital retinal blinding disease

M Menotti-Raymond, KH Deckman… - … & visual science, 2010 - iovs.arvojournals.org
Purpose.: To elucidate the gene defect in a pedigree of cats segregating for autosomal
dominant rod–cone dysplasia (Rdy), a retinopathy characterized extensively from a clinical …

Restoration of vision in the pde6β-deficient dog, a large animal model of rod-cone dystrophy

L Petit, E Lhériteau, M Weber, G Le Meur… - Molecular therapy, 2012 - cell.com
Defects in the β subunit of rod cGMP phosphodiesterase 6 (PDE6β) are associated with
autosomal recessive retinitis pigmentosa (RP), a childhood blinding disease with early …

Epidemiology and clinical presentation of canine cataracts in France: a retrospective study of 404 cases

E Donzel, L Arti, S Chahory - Veterinary ophthalmology, 2017 - Wiley Online Library
Objective To determine the epidemiology and the clinical presentation of cataracts in a
population of dogs in France. Procedures Records of dogs affected by a cataract presented …

AAV-mediated gene therapy halts retinal degeneration in PDE6β-deficient dogs

V Pichard, N Provost, A Mendes-Madeira, L Libeau… - Molecular Therapy, 2016 - cell.com
We previously reported that subretinal injection of AAV2/5 RK. cpde6β allowed long-term
preservation of photoreceptor function and vision in the rod-cone dysplasia type 1 (rcd1) …