The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

Primary aldosteronism (PA) represents the most common cause of secondary hypertension,
but little is known regarding its adrenal cellular origins. Recently, aldosterone-producing cell …

Context: 11-ketotestosterone (11-KT) is a novel class of active androgen. However, the
detail of its synthesis remains unknown for humans. Objective: The objective of this study …

The adrenal glands are paired endocrine organs that produce steroid hormones and
catecholamines required for life. Adrenocortical carcinoma (ACC) is a rare and often fatal …

Primary aldosteronism is a secondary hypertensive disease caused by autonomous
aldosterone production that often caused by an aldosterone-producing adenoma (APA) …

Our group previously purified human and rat aldosterone synthase (CYP11B2 and
Cyp11b2, respectively) from their adrenals and verified that it is distinct from steroid 11β …

Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner
mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high …

Background. The immunohistochemical detection of aldosterone synthase (CYP11B2) and
steroid 11β‐hydroxylase (CYP11B1) has enabled the identification of aldosterone …

Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-
threatening condition. Adrenal endocrine activity is maintained through recruitment of …