The number of successful drug development projects has been stagnant for decades despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …
JU Lind, M Yadid, I Perkins, BB O'Connor, F Eweje… - Lab on a Chip, 2017 - pubs.rsc.org
Microphysiological systems and organs-on-chips promise to accelerate biomedical and pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from …
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life- threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 …
Quantifying small, rapidly evolving forces generated by cells is a major challenge for the understanding of biomechanics and mechanobiology in health and disease. Traction force …
D Strimaityte, C Tu, A Yanez, I Itzhaki… - … applied materials & …, 2022 - ACS Publications
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are considered immature in the sarcomere organization, contractile machinery, calcium transient, and …
The heart wall tissue, or the myocardium, is one of the main targets in cardiovascular disease prevention and treatment. Animal models have not been sufficient in mimicking the …
Current biomarkers for myocardial infarction (MI) diagnosis are typically late markers released upon cell death, incapable of distinguishing between ischemic and reperfusion …
Cardiac tissue development and pathology have been shown to depend sensitively on microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo …
Y Hong, Y Zhao, H Li, Y Yang, M Chen… - … in Bioengineering and …, 2023 - frontiersin.org
The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major challenge to further expand the scope of their application. Over the past years, several …