Mitochondrial membrane lipids in the regulation of bioenergetic flux
Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …
Elamipretide for Barth syndrome cardiomyopathy: Gradual rebuilding of a failed power grid
HN Sabbah - Heart failure reviews, 2022 - Springer
Barth syndrome is a rare and potentially fatal X-linked disease characterized by
cardiomyopathy, skeletal muscle weakness, growth delays, and cyclic neutropenia. Patients …
cardiomyopathy, skeletal muscle weakness, growth delays, and cyclic neutropenia. Patients …
In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial
B Roshanravan, SZ Liu, AS Ali, EG Shankland, C Goss… - PloS one, 2021 - journals.plos.org
Background Loss of mitochondrial function contributes to fatigue, exercise intolerance and
muscle weakness, and is a key factor in the disability that develops with age and a wide …
muscle weakness, and is a key factor in the disability that develops with age and a wide …
[HTML][HTML] A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties
RA Ishkaeva, DV Salakhieva, R Garifullin… - Current Research in …, 2023 - Elsevier
We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular
delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell …
delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell …
Interventions with Potential to Mitigate Injection Site Reactions Following Subcutaneous Elamipretide Administration: A Phase 1, Crossover Study
A Sullivan, S Bergheanu, L Kropp, L Zhang… - Authorea …, 2023 - advance.sagepub.com
Background and Purpose: Elamipretide is a mitochondrial-targeting agent being developed
for the treatment of mitochondrial dysfunction-associated diseases. While prior studies have …
for the treatment of mitochondrial dysfunction-associated diseases. While prior studies have …