Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

It has become clear that reactive oxygen species (ROS) contribute to the development of
hypertension via myriad effects. ROS are essential for normal cell function; however, they …

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical
treatments available. The generation of myofibroblasts, which are critical for fibrogenesis …

Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant
physiological and pharmacological effects. In this review we summarize data from numerous …

The widely distributed TRPV4 cationic channel participates in the transduction of both
physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and …

Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate
a spectrum of bioactive lipid mediators from endogenous substrates. However, studies …

Abstract Transient Receptor Potential Vanilloid 4 (TRPV4) is a broadly expressed,
polymodally gated ion channel that plays an important role in many physiological and …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …

Background: Neurovascular coupling (NVC) is the mechanism whereby an increase in
neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …