Human genetic basis of severe or critical illness in COVID-19

XS Ji, B Chen, B Ze, WH Zhou - Frontiers in cellular and infection …, 2022 - frontiersin.org
Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has led to considerable morbidity and mortality …

Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

P Li, J Hu, Y Liu, X Ou, Z Mu, X Lu, F Zan, M Cao… - PLoS …, 2023 - journals.plos.org
Bat coronavirus RaTG13 shares about 96.2% nucleotide sequence identity with that of
SARS-CoV-2 and uses human and Rhinolophus affinis (Ra) angiotensin-converting enzyme …

[HTML][HTML] Binding affinity between coronavirus spike protein and human ACE2 receptor

MHH Shum, Y Lee, L Tam, H Xia, OLW Chung… - Computational and …, 2024 - Elsevier
Coronaviruses (CoVs) pose a major risk to global public health due to their ability to infect
diverse animal species and potential for emergence in humans. The CoV spike protein …

SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense

X Ju, Z Wang, P Wang, W Ren, Y Yu, Y Yu, B Yuan… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the
global pandemic of COVID-19. SARS-CoV-2 genome encodes a main protease (nsp5, also …

Predictive Factors and ACE-2 Gene Polymorphisms in Susceptibility to Long COVID-19 Syndrome

D Varillas-Delgado, C Jimenez-Antona… - International Journal of …, 2023 - mdpi.com
Long COVID-19 syndrome is present in 5–10% of patients infected with SARS-CoV-2, and
there is still little information on the predisposing factors that lead to its development. The …

Inducing enhanced neutralizing antibodies against broad SARS-CoV-2 variants through glycan-shielding multiple non-neutralizing epitopes of RBD

Q Zhang, Y Yang, J Lan, Z Wang, Y Gao, X Li… - Frontiers in …, 2023 - frontiersin.org
Introduction Since the outbreak of SARS-CoV-2, vaccines have demonstrated their
effectiveness in resisting virus infection, reducing severity, and lowering the mortality rate in …

GSTO1, GSTO2 and ACE2 Polymorphisms Modify Susceptibility to Developing COVID-19

T Djukic, G Stevanovic, V Coric, Z Bukumiric… - Journal of Personalized …, 2022 - mdpi.com
Based on the close relationship between dysregulation of redox homeostasis and immune
response in SARS-CoV-2 infection, we proposed a possible modifying role of ACE2 and …

Genetic diversity and evolutionary dynamics of the Omicron variant of SARS-CoV-2 in Morocco

S El Mazouri, A Essabbar, T Aanniz… - … and Global Health, 2024 - Taylor & Francis
Among the numerous variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) that have been reported worldwide, the emergence of the Omicron variant has …

[HTML][HTML] A substitution at the cytoplasmic tail of the spike protein enhances SARS-CoV-2 infectivity and immunogenicity

Y Li, X Zhang, W Tai, X Zhuang, H Shi, S Liao, X Yu… - …, 2024 - thelancet.com
Background Global dissemination of SARS-CoV-2 Omicron sublineages has provided a
sufficient opportunity for natural selection, thus enabling beneficial mutations to emerge …

The impact of COVID-19 on accelerating of immunosenescence and brain aging

L Müller, S Di Benedetto - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly
impacted global health, affecting not only the immediate morbidity and mortality rates but …