RNA-binding proteins balance brain function in health and disease
R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …
decay provides an important regulatory layer in many if not all molecular pathways …
The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex
AR Tee, JR Sampson, DK Pal, JM Bateman - Seminars in cell & …, 2016 - Elsevier
Understanding the development and function of the nervous system is one of the foremost
aims of current biomedical research. The nervous system is generated during a relatively …
aims of current biomedical research. The nervous system is generated during a relatively …
High-throughput identification of RNA localization elements in neuronal cells
Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of
them, though, the sequence elements that regulate their localization are unknown. To …
them, though, the sequence elements that regulate their localization are unknown. To …
Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Abnormalities in neocortical and synaptic development are linked to neurodevelopmental
disorders. However, the molecular and cellular mechanisms governing initial synapse …
disorders. However, the molecular and cellular mechanisms governing initial synapse …
Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro
While evolution is often considered from a DNA-and protein-centric view, RNA-based
regulation can also impact gene expression and protein sequences. Here we examine …
regulation can also impact gene expression and protein sequences. Here we examine …
The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation
Reversible monoubiquitination of small subunit ribosomal proteins RPS2/uS5 and
RPS3/uS3 has been noted to occur on ribosomes involved in ZNF598-dependent mRNA …
RPS3/uS3 has been noted to occur on ribosomes involved in ZNF598-dependent mRNA …
Accelerating functional gene discovery in osteoarthritis
NC Butterfield, KF Curry, J Steinberg… - Nature …, 2021 - nature.com
Osteoarthritis causes debilitating pain and disability, resulting in a considerable
socioeconomic burden, yet no drugs are available that prevent disease onset or …
socioeconomic burden, yet no drugs are available that prevent disease onset or …
Translating neural stem cells to neurons in the mammalian brain
The mammalian neocortex underlies our perception of sensory information, performance of
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …
Herpes simplex virus ICP27 regulates alternative pre-mRNA polyadenylation and splicing in a sequence-dependent manner
S Tang, A Patel, PR Krause - Proceedings of the National …, 2016 - National Acad Sciences
The herpes simplex virus (HSV) infected cell culture polypeptide 27 (ICP27) protein is
essential for virus infection of cells. Recent studies suggested that ICP27 inhibits splicing in …
essential for virus infection of cells. Recent studies suggested that ICP27 inhibits splicing in …
RNA on the brain: emerging layers of post‐transcriptional regulation in cerebral cortex development
Embryonic development is a critical period during which neurons of the brain are generated
and organized. In the developing cerebral cortex, this requires complex processes of neural …
and organized. In the developing cerebral cortex, this requires complex processes of neural …