Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …

Glycosaminoglycans (GAGs) are complex linear polysaccharides expressed in intracellular
compartments, at the cell surface, and in the extracellular environment where they interact …

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,
such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the …

The molecular mechanisms underlying chikungunya virus (CHIKV) infection are poorly
characterized. In this study, we analyzed the host factors involved in CHIKV infection using …

Glycosaminoglycans (GAGs) have been shown to bind to a wide variety of microbial
pathogens, including viruses, bacteria, parasites, and fungi in vitro. GAGs are thought to …

Although effective hepatitis C virus (HCV) antivirals are on the horizon, a global prophylactic
vaccine for HCV remains elusive. The diversity of the virus is a major concern for vaccine …

Androgen deprivation therapy is given to suppress prostate cancer growth; however, some
cells continue to grow hormone-independently as castration-resistant prostate cancer …

A modified form of heparan sulfate (HS) known as 3-O-sulfated heparan sulfate (3-OS HS)
generates fusion receptor for herpes simplex virus (HSV) entry and spread. Primary cultures …

ABSTRACT Hypervariable region 1 (HVR1) of envelope protein 2 (E2) of hepatitis C virus
(HCV) serves important yet undefined roles in the viral life cycle. We previously showed that …

Although potent direct-acting antiviral drugs for the treatment of chronic hepatitis C virus
(HCV) infection are licensed, there are more than 70 million individuals suffering from …